A Comparative Study of Intravaginal Misoprostol Vs Intra Cervical Dinoprostone Gel for Induction of Labour

Induction of labour is a common need in obstetrics ward. There are various complications and drug side effects associated with it. This study has been designed to compare the safety and efficacy of 50μg intra-vaginal misoprostol (PGE1 analogue)with 0.5mg intracervical dinoprostone gel (PGE2). . 40 pregnant women with different indications of induction of labour participated in the study. They were randomized to receive either 50 μg vaginal misoprostol 6-hourly or 0.5 mg of intracervical dinoprostone gel 12 hourly. The maternal and foetal outcome were judged in terms of Bishop's score, induction to delivery interval, need for oxytocin for augmentation of labour, mode of delivery, maternal and foetal side effects. The results show induction-Delivery intervals were significantly shorter and the requirement of oxytocin was less for augmentation of the labour in the tab. misoprostol group than dinoprostone gel group. Intra vaginal misoprostol is an effective agent for induction of labour than intra cervical gel. Intravaginal misoprost is an effective agent for induction of labour than intracervical gel. All these result were statistically significant. Very few maternal and foetal side-effects noted. There was no significant difference in foetal outcome seen. Therefore, it can be concluded that misoprostol is easy to administer and is cheap, stable at room temperature, effective drug for induction of labour. * Corresponding Author : Archana Copyright 2010 BioMedSciDirect Publications. All rights reserved. c